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Serum antioxidant vitamins levels in non- insulin- dependent diabetes mellitus subjects in Sokoto, Nigeria

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dc.contributor.author Muhammad, A
dc.contributor.author Mansur, L
dc.contributor.author Frank, M
dc.contributor.author Yusuf, S
dc.contributor.author Lawal, S. B
dc.date.accessioned 2017-10-30T14:07:37Z
dc.date.available 2017-10-30T14:07:37Z
dc.date.issued 2005-05-07
dc.identifier.uri www.ajol.info/journals/biokem
dc.identifier.uri http://hdl.handle.net/123456789/198
dc.description.abstract Evidence is accumulating that most of the degenerative diseases including diabetes mellitus have their origin in deleterious free radical reactions. Humans are well endowed with antioxidant defences primarily by free radical scavengers, such as ascorbic acid, alpha–tocopherol, beta–carotene, and trace elements. Deficiencies of these micronutrients may increase susceptibility to these diseases and the associated complications. Antioxidant vitamins (vitamins A, E and C) were estimated in one hundred and fifty (150) non insulin dependent diabetes mellitus (NIDDM) patients attending the outpatient clinic of the Usmanu Danfodiyo University Teaching Hospital, Sokoto, Nigeria. The results obtained were compared to those of One hundred and fifty (150) apparently healthy non-diabetic subjects. Serum glucose of the diabetic patients (13.59 + 4.85mM) was significantly higher (P<0.05) than the control value (5.19 + 1.15mM). Vitamins A, E and C concentrations were significantly lower (P<0.05) in diabetic patients. Twenty Nine percent of the male and female diabetic patients had severe vitamin A deficiency (VAD) while 23% and 16% of them respectively had moderate VAD. The prevalence of vitamins C and E deficiencies among NIDDM subjects was also high. The results indicated significant (P<0.05) negative correlation between serum glucose and each of the antioxidant vitamin levels (r= -0.41, -0.5 and -0.05 for vitamins A, E and C respectively). These results suggest that NIDDM subjects of the study area have low serum levels of antioxidant vitamins and the concentration of these vitamins correlated negatively with blood glucose level en_US
dc.language.iso en en_US
dc.publisher Nigerian Society for Experimental Biology en_US
dc.subject Department of Biochemistry en_US
dc.subject Deparment of Human Physiology en_US
dc.title Serum antioxidant vitamins levels in non- insulin- dependent diabetes mellitus subjects in Sokoto, Nigeria en_US
dc.type Article en_US

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