Abstract:
A comparative study was carried out to investigate the efficacy of the aquous extract of
Terminalia avecinnoides
alone
and its combination with diminazene
aceturate
.
Thirty Wister albino rats of both sexes weighing between 250
-
260gms
were distributed into six groups (A
-
F) of five rats each. All the rats in groups A
-
E
were infected with 0.5ml of blood
containing 1x10
6
Trypanosoma brucei brucei
. Rats in group F were uni
nfected and untreated (control). Rats in groups A
-
D
were treated 5 days post
-
inoculation orally, with 3.5mg/kg Berenil
®
alone
,
80mg/kg plant extract alone
,
80mg/kg extract
plus 1.75 mg/kg Berenil
®
and
1.75 mg/kg Berenil
®
respectively were
infected
Group E
, not treated. Treatment with extract
alone resulted in reduction in parasitaemia, but
wa
s not
curative
. However,
Berenil
®
treatment alone and its combination
with
the extract resulted in
the clearance of the parasite
.The result obtained suggests that
T. a
vecinnoides
alone and its
combination with Berenil
®
offer great potentials as alternative products for the treatment of trypanosomiasis.
